Platelets are formed in the cytoplasm of a very large cell, the megakaryocyte.
The cytoplasm of the megakaryocyte fragments at the edge of the cell.
The condition also is characterized by proteolysis of platelet α-proteins such as platelet factor V and von Willebrand factor, further interfering with clot function, and with increased uPA messenger RNA levels, particularly during megakaryocyte differentiation.
"Our study indicates that the dysregulation of PLAU in Quebec platelet disorder extends beyond megakaryocyte lineage, to involve other cells of the myeloid lineage," the investigator said.
Lagrue-Lak-Hal AH, Debili N, Kingbury G, Lecut C, Le Couedic JP, et al. (2001) Expression and function of the collagen receptor GPVI during megakaryocyte maturation.
Boer AK, Los EL, Esselink MT, Vellenga E (2005) Stem cell factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase.
EPO - and SCF-induced STAT5 phosphorylation was largely restricted to the megakaryocyte-erythroid progenitor (MEP) compartment, while G-CSF as well IL-3 and GM-CSF were most efficient in inducing STAT5 phosphorylation in the myeloid progenitor compartments.
TPO influences megakaryocyte (MK) development by controlling proliferation, differentiation, survival and endoduplication
Hundred thousand 105 whole BM cells were assessed for megakaryocyte progenitor activity in a CFU-Mk assay, MegaCult-C (Stem cell Technologies, Vancouver, CA) per the manufacturer's instructions.
We hypothesize that SHIP might control megakaryocytopoiesis through effects on proliferation of megakaryocyte progenitors (MKP) and megakaryocytes (MK).