penicillinase definition

  • noun:
    • some of numerous enzymes which are made by particular bacteria, including most strains of staphylococci, which hydrolyze and inactivate penicillin. These are generally used in medicine to treat allergic reactions to penicillin. Also called beta-lactamase.
    • a certain kind of beta-lactamase showing specificity for penicillins.
    • a chemical which damages the antibacterial task of penicillin by hydrolyzing the amide bond in beta-lactam band. Numerous penicillinases tend to be known, as they are generated by numerous germs. The production of penicillinase is among the systems through which bacteria could become resistant to penicillins. Penicillinase manufacturing in a variety of microbial types could be caused, for example., it may occur only when stimulated by the existence of penicillin in culture method, or it may be constitutive, for example., it would likely take place anytime the cells are creating protein. Molecular weights of the numerous penicillinases often cluster near 50,000.
    • chemical produced by specific micro-organisms that inactivates penicillin and results in opposition to that antibiotic drug

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