perhaps not opposing; not standing in the way or contradicting; not availing to the contrary.
With after noun, or clause with that: despite, or perhaps in spite to the fact that; although.
Synonyms Notwithstanding, despite, Despite, for many. Notwithstanding may be the least emphatic; it calls interest with some emphasis to an obstacle: as, notwithstanding his childhood, he made great progress. In spite of and despite, by the strength of this term spite, point mostly to energetic opposition: since, regardless of their maximum attempts, he was beaten; and, figuratively, to great obstacles of any kind: because, despite all hindrances, he attained the full time appointed. Despite is pretty loftier plus poetic as compared to others.
accompanied by a clause with this omitted: In spite of the truth that; although.