to utilize the hands in dexterous operations; doing hand work
to deal with, or act on utilizing the hands, as in imaginative or mechanical operations; for this reason, overall, to at the mercy of particular mechanical operations or to some way of managing, organizing, combining, etc.: as, the chemist workouts great care in manipulating his products and device.
Figuratively, to operate upon by contrivance or impact; affect in a particular method by a definite course of treatment; manage; particularly, to handle insidiously; adapt or apply to a person's very own purpose or advantage; treat or make use of falsely or deceptively: since, to control accounts or even the details of record (with all the purpose of falsifying them).
to make use of the hands, like in technical or imaginative functions, medical experiments, mesmerism, etc.: as, to manipulate nicely or successfully.