- Isabella I Generally "Isabella the Catholic.” 1451-1504. Queen of Castile (1474-1504). The woman relationship in 1469 to Ferdinand V of Castile and León (later Ferdinand II of Aragon) marked the start of a unified Spanish state. Isabella sponsored the voyages of Christopher Columbus.
- the queen of Castile whose marriage to Ferdinand of Aragon in 1469 noted the beginning of the current condition of Spain; they instituted the Spanish Inquisition in 1478 and sponsored the voyages of Christopher Columbus in 1492 (1451-1504)